I hope you're gonna stick with a male protagonist, it certainly sounds interesting and if you were to actually go through with it it would most likely turn out to be something that's pretty unique, but i firmly believe that female protagonists don't fit in your games all that much.
I'm not pretending to be an expert when it comes to adult games, mainly because i'm extremely picky when it comes to artstyle so i haven't really played all that much, but from my personal experiece, i don't think a game with a female lead can ever match the corruption/NTR that male protag games have, especially when the game is as slow paced as HC3.
I think female protagonists only work in games where the story is only secondary to the sex scenes and where the player has complete freedom over mostly everything, like the ONEONE1 games (Samurai Vandalism) where you can just walk up to anyone and ask them to have sex with you. It might sound a bit odd but whenever i'm playing a game with a female lead i always feel like i have too much control over things, which is definitely not a bad thing, Samurai Vandalism is a good example of that, but it's not something you would want your players to have in an NTR game like yours (that is, if you want your female protag game to have NTR in it, obviously).
There is also the question of Partial POV and freeroam events, both of which is loved by many people but is something that i don't see working in a game where you're controlling the person who's supposed to be IN the freeroam event.
I remember you saying once that you want to make another game like Merry H-mas in the future, where the game is just a short story instead of a several year commitment, if you're REALLY thinking about making a female protag game then i would definitely recommend making a shorter game like that out of it. Experimenting is fine but this would be such a leap from what we have now that if you were to start a project that you're gonna develop for several years to come, you might overall lose more people than gain from it.