At the risk of this being off-topic to the game (but certainly on-topic to the discussion):
ANGLE (Almost Native Graphics Layer Engine) is a library that sits between OpenGL and DirectX to "translate" the OpenGL commands to the hardware acceleration API available on the system, Direct3D being part of DirectX. It's
supposed to be for WebGL in web pages (or at least was originally), but it's been used elsewhere along the way (I've never developed graphics applications, so someone may have better specifics). Your log showed the renderer chosen was Angle, so "Force OpenGL" removes the middleman as most graphics cards (Nvidia, Intel and AMD) now support OpenGL directly.
Since OpenGL works, the issue may be the drivers for the card or something with the ANGLE library on your PC (or maybe DirectX, for that check your Windows updates).
darkhound1 may know something about how that works with Ren'Py and his game and his images (since you seem to have no issues in other games), but since we got it working I'd let him work on the game
.
If OpenGL did NOT work, but Software DID, I would be concerned something was corrupted on the card or driver since NO path to the cards commands was available.
NOTE: Again, this is based on a basic understanding of how this stuff works since I've not done it personally. I coulda just got lucky