Your old save don´t affect the game engine, it only stores the advantages of your player, the stats of your girls and the groups.
Never touched an ini file so far.
So I only can recommend you make a clean new install and test again.
If running well transfer your old stuff (UserData, MyMods) into the new game and test again.
At last you can try an update again, for the game alone you need only to activate the categories "Sideloader Modpack" and eventually "Sideloader Bleeding Edge" (only if you have activated Experimental Mode).