Absolutely. Switch on your BepInEx console (if it's not) and take a look how many hundreds of mods are being loaded, one after the other. Many mods have graphical elements to them, combined together it becomes a heavy load to lift, until it's loaded in cache/ram...
Second part to this is if you have something like Hanmen's next generation graphics and use graphic mode which improves the quality A LOT! But it demands a lot video,ram and CPU resources (HDD space as well

). I have RTX 3070, 32 GB ram, ryzen 7 and it still takes a considerable time to load.
Of course, you can always test things to be sure. Get clean HS2 from somewhere, use only Illusion official updates and no BepInEx, Manly Marco patches, or betterrepack stuff and guess what ? The loading speed will skyrocket (if your PC is good of course).