I'm also on AMD CPU+GPU and experiencing eternal loading screen.
This damned new JS-based RPGMaker engine. It's so fucked up. This game takes 4GB of RAM. Whoever decided to migrate the RPGMaker engine from Ruby to JS was a madman. Huge mistake.
PS: Running in Windows 7 compatibility mode, as others have suggested, has fixed the issue.
Pretty sure this isn't RPG Maker. The index.html looks nothing like RPG Maker.
Based on the c2runtime.js I'm guessing this game was made with Construct 2:
You must be registered to see the links
Which uses a nwjs node system to have the game run in basically a chrome browser that looks like an application window.
The size of the game has nothing to do with RPG Maker, nor necessarily with Construct2 or Javascript.
Rather this seems related to the dev unpacking & preloading all the graphical assets.
This stores them in your RAM and ensures they can be loaded immediately when needed without loading delays.
This may be a feature of Construct2 or just the dev's decision to avoid having to load in the assets at a later point.
So, not a RPG Maker, JS or other issue, but the result of all the images being preloaded.
Also, fun fact:
RPG Maker, at least in MZ, has a ridiculously strict asset loading system where it basically, at every scene change, UNLOADS ALL ASSETS to free as much RAM as possible.
Literally destroys all cached assets. Then it reloads the bare bones that are needed for the new scene (system & window images) and only then it loads the minimum of what's needed to display the next scene.