It's intensely finicky. What I've found works best is if you ignore the Katherine quest line so you can keep the rum for yourself, and take the whiskey and chardonnay once Frank's been laid out. Save your game (in case something doesn't work) and then climb into the hot tub and drink two of the bottles in your inventory. Then talk to Vickie and have her perform her experiment on you three times. After the third time, drink the last bottle in your inventory. You should be drunk enough to proceed but not so drunk that she ignores you.
Basically, you just need to let some of the alcohol wear off before you drink the third bottle, or you'll be too drunk. That's the method I've been using and I haven't had a problem.
The water bottle is the empty vodka bottle in the cabinet/on the table (depending on what version you're playing). To get it, you have to inspect it and then ask Frank about it. It's buggy, though. If the dialogue doesn't pop up after you inspect it, open the console and use 'player inventory vodka' (without the quotes). That will add the vodka to your inventory.
What exactly do you mean by 'the animations don't work correctly.' Could you provide screenshots or something as an example?
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