I am fairly sure that I recall being able to continue interacting with her after taking her virginity in a previous playthrough and rebuild her affection and trust, but at the time nothing sexual ever came up again except maybe the one where she tries to pleasure herself on your knee. I don't know if that has changed - that was the reason for asking - but that was my experience from a prior version.
It's a shame, too. I just find the concept of this woman who is seemingly completely oblivious the differences between men and women, unaware of the mere existence of sexual pleasure and ignorant of sex extremely appealing. I would love to continue a slow and tender process of teaching her about these things and experience her wonder at, and gratitude for learning... maybe even eventually get her pregnant and have her marvel at that unexpected progression.
I suppose if nothing comes up I might try to make a hard save to return to if things go badly, take her virginity (which reminds me, I also wish there was a way to have her take the initiative for that rather than me having to do it... like she maybe got so eager that, after you maneuvered her into position, she was the one who thrust her hips), rebuild her affection and trust and see if anything happens. Might end up cheating for that one, though, because that's potentially a lot of time to sink into figuring out if there's more or not.