I'm fine with the lesbian part but really not a fan of other dicks in my adult games.
Plus this is a 40k setting, which is usually grim and dark and uncompromising, so definitely not a playground for happy consensual girl love. Chances are there's gonna be plenty of domination and submission, humiliation, bdsm (it's a fucking Inquisitor after all) and possibly sexual violence.
With a female protagonist there's a high chance the player will be mostly on the receiving end of all that kinky shit, especially once other races are introduced (Orcs, Chaos, Tyranids).
Since I'm neither submissive nor interested in dominating a bunch of dudes I'll probably have to stay clear of this, no matter how much I like the setting.