I'm in year 11 and maxed out on everything.
That's not a bad thing in itself but you might want to give a few more options on spending essence.
Like buying action points or sperm. As it is now, I'm just clicking through to convert, which just takes unneccessarily long, considering you could implement the option for that.
Also you might want to adjust the costs in the essence store.
I'd increase the costs of raised max stuff with each purchase.
In theory you could get rid of the maximum in total because the costs per increment would be in the thousands at some point and at least there would be a money dump that way.
Also also a way to increase action points would be nice.
Also also also a way to do an action several times to fasten up the gameplay. It's sort of annoying to wait for 2 screens to play on an action you need to do 10 times in a row.