Well you will get a bunch of Sadistic passives no matter what. The best thing you can do, is avoiding stuff like getting a Sadistic Orgasm or the use of Taunt. But with that said, it is possible, to do a pure run on Prisoner Mode no problem. The most important Stat is the Mind Stat, since the higher it is, the more you will reduce Desires and deal more Damage with Ki. Stuff like Skewer and Cleaver is important. Also avoid fighting in certain rooms until you are ready unless you go for a Rush Build but for that, you need to ask someone, that does Rush Builds, since I always take my time.