I was worried about this too, but yesterday I tried it. It's not exactly the same, but it's possible.
I ended up writing an entire engine instead of using rpgm. I'm not sure if this is the best approach, but it's faster to write from scratch rather than keep testing with the current rpgmv engine. I'm still using NW.js and Pixi, though.
the artwork style consist of 5 layer. base_color define shape, shadow cast define it volume, light, hightligh, and overlay shadow that cast from another part. after find the correct rgb its seems to work. with this way possible to color its skin dynamically