Admittedly, formulas for cost effect of actions are so convoluted in this game that you will be getting some crazy outcomes at times, especially on higher difficulty modes.
Generally, the sluttier Karryn becomes the more pleasure damage she receives in almost any aspect of her sensuality. You can see this in her sensitivities stats. When everything goes pink and triple digits, she's so ridiculously oversexed that it's difficult to control her actions. Which should not frustrate the player going through a slut run at all. Similarly with her desires. Slutty Warden should have them maxed out at all times, unless you're aiming for a technical virgin slut run, in which case you need to keep her pussy cool.
By default, all actions cost stamina and that cost grows exponentially when comboed, regardless of her her level of dexterity or endurance. It is therefore wise to let her rest from time to time by using pleasure stance or energy expanding actions (flaunt, taunt, etc). Again, total stamina depletion is not a big deal for sluts - the battle is not yet lost when she falls down exhausted as she can still subjugate prisoners sexually as a passive sextoy.
The game's rules are purposefully tilted to the player's disadvantage to convey this idea of giving up control and still reaping benefits from it. It would be utterly frustrating and game-breaking if you couldn't restore any Order when defeated, but you can! The more inmates she satisfies sexually, the more order is restored, so a defeat gangbang featuring 16+ inmates will pacify the prison significantly. A well-built slut will therefore be incentivized to look for a defeat, especially as repeated defeat scenes bring more slutty passives.