some responses to this in no particular order
you should try a slut run and see how it changes your strategy
I
have done a few slut runs, they are nice for getting some very useful titles like the +charm ones, the -order ones, and the sadist+masochist ones.
Also this IS an H-game after all lol
I additionally did 2 of the Descensions, From a Failed State and A Different Mindset, as a slut because the conditions imposed by those runs makes it very hard to win with purity.
Slut runs are way simpler and easier than purity runs, but they take waaaay longer. Most of the tips I posted were about helping people with pure runs for that reason, if someone can beat the game on prisoner being pure, slutty should be easier.
Primary stat for slut karryn is Endurance, secondary stats are Mind and Dexterity. Obviously you want the first energy and stamina edicts too.
Accepting drinks(? or maybe just some other part of the job, not sure) in the waitress sidejob is a good way to rapidly gain endurance exp.
Also you are gonna want mostly different accessories for slut karryn obviously. Should be easy to figure out, especially since you will have more money.
If you have high Mind and can get to over 200% and 300% pleasure thresholds before orgasm using the delay orgasm willpower skill, you can earn two very powerful passives for a slut karryn.
The scariest enemy for slut karryn are slimes because they can basically act as 3 enemies at once while the rest also hit her with pleasure attacks. Try to eliminate other enemies ASAP for this reason so they don't hang around while the slime fucks karryn.