If I remember correctly, Nanos give you good money in the serums you put them into.
build your foundation. get a decent income. seduce 1 or 2 girls so they're you're go-to fuck buddies for a steady stream of clarity (Steph is usually a good choice here or your sister/mum; Alexia/Sarah/Ophelia are also good choices). a steady stream of clarity is very important to ensuring you have full access to research
at the start, sex is going to be more 'business-like' until you get comfortable with the game and are able to push the game limits as you please. your sex goals should be to maximize clarity. only after your financials + clarity (and personal stats maxed) are secure, then you break down taboos relatively easily.
consistent drugging with nanobots help a lot with sex opinions (for example: breeding nanobot impacts likes submissiveness, likes bareback sex, likes creampie, likes vaginal, etc), when your company policies are set up, you're able to have your employees drugged everyday so they'll be going from 'hates creampies' to 'love creampies' pretty quickly.
trance also helps a lot and is very easy to reach once you've built the foundation. late game serum trait has a 'trance inducer' so you can instantly trance a girl up once your research has progressed enough. until you reach that point, i personally max my MC stamina + 'oral sex skills' and 'kneeling oral' the girl until she comes her brains out. unless she 'hates receiving head', she'll orgasm multiple times in the sex session and fall into a deep trance from all the orgasms.
edit: for increasing a girl's sluttiness "easily" i'd say there are 3 ways.
first method, use a ton of sluttiness traits in a serum. just stack them like crazy. you should be able to get +40 sluttiness relatively easy (you'll need to have unlocked multiple tiers of research for this)
second method, make the girl orgasm a lot. most girls will increase sluttiness by +1 if you make them cum from a sex position they don't find boring.
third method, make them watch you fuck. look for an opportunity where the girl is alone. tell your fuck buddy to follow you and bring your fuck buddy along (that location should have you, fuckbuddy, and girl you want to increase sluttiness stat of - note she should not be your girlfriend or she might break up with you) you then proceed to slowly sex up the fuck buddy in front of the voyeur. what i mean is, don't go straight into hard anal or piledriver vaginal. the voyeur's sluttiness will determine how much depravity they're willing to watch.
usually it's something like:
0-30 sluttiness (likes watching kissing/groping)
30-50 sluttiness (likes watching oral/tit fuck)
50+ sluttiness (likes watching penetration)
you'll know what their limits are because their sluttiness will increase by +1 or +2 if they 'like' what they see.
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