I just thought of something. In the last update mayas comments made it pretty clear their relationship was a codependent one. And that she also did build him back up when he broke. But after the last reset we have clearly seen that he now depends on ami to do it. And she also knows what to do -sort of- so that cant be the first one. And i will at least for now ignore any possibility that maya lied or there is sort of retconning going on. So how did that switch from maya to ami?
I think that didnt happen on actual choice, but just because maya is self reliant, while ami is not. So he had to because maya would survive, while ami would not.
And i still remember that theory about his suicide. And i still dont buy it. But what if the loops started because of the death of someone that is currently alive? I mean i have long since the theory that maya has gotten punished in one way or the other with her role in the loops? So what if before the loops started, akira's and maya's codepency let akira to abandone ami and that caused her suicide/death and that lead to the start of everything.
Hm, yeah, i am not fully convinced myself. But it would explain some things. I mean if maya was so important to him that it caused him to abandon ami, of course it is no surprise that he also did abandon nikki and noriko. Maybe all that just happened because maya wanted it to happen. That she was involved has been implied pretty heavy for a long time anyway.
Over the years, Maya and Sensei would apparently "fix" eachother after they "break":
And by "break", Maya seems to mean "act all suicidal". What Sensei recently went through where he was bedridden probably isn't what she's referring to, as she doesn't seem used to this kind of breaking like Ami is.
Overall: Considering neither are good at taking care of people, or talking about their feelings, while seeing sex as basically a cure all, and both love Ami, I'm guessing when they got sad, they'd convince/force eachother to forget their problems and move on aka "fixing" eachother (in Maya's pov), while Ami kept them alive.
Frankly, this conversation may have spoiled the future:
It's also possible that Maya was actually the one who killed herself:
And Sensei created this world to keep her around (or Ami created this world to keep everyone around, since after Maya bit the dust, Sensei may have followed suit, and then maybe Ayane.)