The main issue with going full genocide is that, you have no more safe haven for you to rest, to resupply and you can't even get to the bank in one piece because due to the morality that will be taken quite a hit, you will alert all guards to go hostile on you and even normal people goes hostile on you.
There is a bit of remedy on that , that is you buy fake papers that help 'normalize' the morality, but it's costly putting your goal to earn 20 gold coins severely hindered. Sure you get a bit more money but also you need to spend money to buy fake papers or else hard to be inside the city with everyone alerted wanted to kill you due to the low morality.
I use sneak , survivor build with stealh perk and the ability to make traps my weapon is a club because at time it activate and clobber enemy in stun while in stun I clobber like hell, yeah hit , run, trap, pot, potions, food , divide and conquer, Musket, I use it to fire then change to another club.
Only work if you able to divide and conquer the enemy one at a time, if you got caught for 2 or more basicallly you're dead. Use rocks, Traps, hide, sneak and clobber from behind.. to get backstab. Trap to make the enemy weaker or even the legs or arms busted so doesn't run that fast or hit harder.