Lona is not the classic hero that can slaughter demons and gods in (fair) combat but you're able to do exactly that in the game if you're playing it smart. You can 'kill' the fortune teller if you want to. It won't be easy but you can do it in the game right now. The orkinds, for instance, have nothing to do with how strong or weak Lona is, it's just that their numbers are almost endless due to all the chaos and strife, it's very easy for them to replenish their numbers. Nobody gives a damn about anybody else and that's why they're able to snag a lot of women for breeding purposes. They're also able to somewhat tame the corruption monsters. The goblin riders use the fleshlings as mounts and in some camps in the Sybaris region you can see they're even breeding abominations to use as mounts and probably also as livestock since it's mentioned in one of the lore notes that the orkinds have trouble with food.
Which simply means that you won't get rid of the orkinds without dealing with the gods' fuckups first. It's either that or all the factions will eventually burn themselves out, abominations and orkinds are parasitic species that need human hosts to reproduce. Once they're gone, they'll go extinct.