That's a huge over statement for example on the last update the only thing that need a specific choice is Camila's content where you need to put Kylie in jail.Due to retcons of previous material and situations, a full save wont do you any real good since the changes often do not trigger any missed events.
You have to constantly re-start the game as of right now.
We almost never break save compatibility and we seldom "retcon" but we sometimes (not that often) add events to earlier part of the games.