There are several mutually exclusive relationships in the game. Lisa and Lauren require separate playthroughs to see all their content, as even taking one as a side girl doesn't give you her scenes, it just adds some flirting. Katrina and Darlene's paths are also mutually exclusive, and depending which job you take, you'll get some different scenes with other girls. More dom/rough content with several LIs if you work in the club.(Example: In the latest update if you work for darlene, Tris gives MC a blowjob in the bathroom, but if you work for Kat, MC facefucks her instead.)
The training week also has 2 versions. If you're on Denise's path, you spend the week with her, otherwise you spend it with Shiela. I have one save with Darlene/Lisa path, and one with Kat/Lauren. I also use URM to see scenes I'd otherwise miss(like the Lisa/Lauren side paths). Not gonna give up Denise's path, but with URM I can change the variable and see the Shiela training week, then just reload and do the Denise week.