Yes, the story is self-contained without relying on plot points from the anime and manga. I don't want to spoil anything because Season 3 of the anime is coming out later this year.
Of course, characters and events from Season 1 and early Season 2 will appear and be referenced, but if something is required to understand what's going on, I'll establish it like a normal story would.
A note for more advanced OPM fans: If you've read the story so far, you've probably pinpointed that this is an alternative universe set in the middle of Season 2 becaused on the early appearance of Do-s and Garou during his early hero hunting days. Personally, I'd say the story is set before the Super Fight Tournament, where Do-s went solo and died on her own.
The story won't be stricly following the webcomic or manga continuity, and the major events of that story and those characters aren't super-important for OPC, which'll focus on the protagonist's growth and their romance with Tats.
There are a few surprises planned for fans of my stuff and fans of OPM.