Yeah, I think I get what you mean. I think Axel's and Seymour's paths could lead to a lot of interesting scenarios, so I'm letting Lena act differently towards them on different playthroughs, but my main one involves a Lena who keeps in control of the situation. For me that could either be by rejecting them before or after leading them on, or by getting involved with them to a certain extent; a Lena who doesn't come crawling back to Axel, but sleeps with him when she wants herself, but rejects him if he asks her to stay the night or to be in a relationship with him again. (Lena: "Sorry, Axel, you had your chance and blew it when you cheated on me. I'm going home now, I need a good night's sleep before meeting Ian tomorrow. I'll call you when I want you to dominate me in bed again, but don't sit up and wait for me, cause my schedule is pretty packed the coming weeks.")
I'm not sure yet if we'll get what we hope for, but as I guess you've noticed yourself, there's signs that both Seymour and Axel will be quite heavily involved from now on. So I suspect there will be several future interactions with them no matter if Lena rejects them or not.