I don't think it is all that weird -- it's common for people to treat people with different degree of respect, and to care about some more than others, depending on personal preferences. Lena is on record as a big fan of Holly even before they meet and get to know each other. In contrast she doesn't hold that high opinion of Louise (not surprising when you can see every day the way Louise can act) and even less about Mike's girlfriend she doesn't know anything about (other than said gf has allegedly smaller bust) So, caring about Holly's feelings more than she cares about Louise's or Mike's girlfriend's, it's easy enough to explain.Dunno. If hurting feelings is what she is avoiding then I don't think she would cheating with Jeremy even though she been friends with Louise for a long time and is her roommate. Same goes for Mike who she knows already has a girlfriend. It is weird that she suddenly becomes goody two shoes when it comes to Holly.
								
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