Ok. I switched to Firefox which solved the save problem (apparently that's got more to do with how Twine saves and browsers work, not so much a fault of the game), then I changed some UI bits to work better on 1920x1080 (set the bottom element of the left side bar to relative, with a bigger margin, and allowing overflow to scroll); while I was at it, I deleted all history control bits cause that seemed to keep throwing up errors, and then I also changed some audio stuff since that had the occasional error too ...
... a bit annoying but ok.
Unfortunately I can't say I felt that the game was worth it. Art is fantastic, the idea is nice. But it feels like it should almost be a puzzle, where you have to figure out how to proceed, and how to do the right things, and then you get some sexy parasite/infestation stuff, and (if we want to talk perfection) you could approach it in different ways.
In reality it felt like I repeated the same thing over and over again, that there were barely any unique scenes, instead everything being very generic, with some random meme's (handholding ...) thrown in for no reason at all. Yes, here, have your werm thing, now do nothing for the rest of the game, aside from repetitive same sex scenes.
dunno if it's just me not clicking with the concept or whatever, but it just seems to be in a weird state ... plus, I actually found an older version on my HDD, and from a quick play not only doesn't it have all the bugs this version have (it has others though...), it also seems to have more content in the later chapters, and some additional mechanics early on. No doubt there's some explanation somewhere (rework etc.) but it just seems really weeeeird to me.
Well. Overall that wasn't a very satisfying experience.