Right at the start there are 2 quests that are missable, "Talk To The Villagers" triggersbif u try to enter Goblin Forest BEFORE talking to Mayor & "Check Point" triggers if u speak with the guards in front of Witch's Hunt BEFORE asking Mayor for other jobs.
If you choose No-Cuck route for Mia when give the option you will not get the quest "Werewolf Hunt".
You can lose the entire Vampire arc (including Oksana's introduction) by killing the vampires in the day. I would assume that getting Oksana killed or losing her (& not using the Oksana Apparition to veto that) would lose "Spread The Good Word" & "Forsaken".