Sinistrem Best use for the super hybrid, as the wiki says, is as a dedicated scout. Use a species with glowing for the potion, along with all the other stats the char gets it'll make it the best scout in the game.
But, that's not all. Make sure you also get the teleport skill on the super hybrid, along with the diluted trait. Turn it into a true dedicated scout, allowing you to teleport across entire maps without having to spend time actually moving. Sure, it might cost you about 75-90 crystals for a normal size portal, but it saves you a lot of time and stamina. If you manage to get a healing spell on it, it also functions as an off-duty healer.
In regards to getting better portals, if you play anything other than 30 days at regular difficulty you'll always overpower everything and anything thrown at you.
Hell, my Challenge Rating 10 Diffuclty 600% strat is the same as my regular strat. Spawn fire elementals, use the first king fight as a cheap XP source (fused elementals - requires Catalyst trait - get 50% bonus XP, adapt them as intelligent for another 1.5x multiplier and if you got it, add Light Affinity for another 50%. You'll be leveling them to 20 pretty quick). Once you get some solid stats on a pair of LV20s then you breed them until they get high genes in mana and magic, then just keep fusing and adapting to give them best possible traits for casters (arcane, infused, intelligent possessed, charging, potential, telekinetic, ancient power, etc.) and make sure you fuse their skills until they get Meteorstorm. Evolve to Firesnake or Fire Nymph, you are set. A LV20 Firesnake with decent genes and meteorstorm can one shot pretty much anything. Worst case scenario, it's magic will be so high that even in melee it'll hit harder than most your dedicated fighters thanks to the telekinetic trait.
Well, that works for druid at least. Pretty sure you can do something similar with Evo and Crea if necessary.