I don't know if it was just me or some kind of bug for I once switched to female using the lab, and then I noticed different responses from the characters where ones I had gone far with seemed to be fine with it while others were weirded out. The actual issue was that I couldn't get access to the romance menu on certain characters I hadn't progressed much with. The issue with this was that these characters gave the A-okay but it still had me stuck at the previous menu. I had to start a new save and I didn't mess around with the sex changer and I haven't had that issue so far.Start a new game and youll see.