Aside from not getting locked on any other main route, I don’t remember any issues. Though, your Blake should lose anal virginity at some point before that, otherwise he might not be into the idea of taking Suya’s massive cock.
Nope, my Blake is on Suya-only and was a "virgin" when they had sex the first time.
There's actually a scene where Blake mentions it's his first time with a dick, which surprises Suya big time.
So, I'm planning a new Playthrough with Suya, is there any nogo i have to consider?
Most important in my opinion is to decide which route of her you wanna go.
Since she takes a looong time to realize that you actually are interested in her, replaying for both routes is rather tedious.
The walkthrough helps a bit, though managing your dom/sub points and skip the right sex opportunity for the dom route is a little bit tricky.
Also bimbo points can screw you over.
Furthermore she is not compatible with Iris, but has a minor route with Reese, which I almost missed because the walkthrough never really mentions it.
There is the possibility to have interactions with Felix and her, but I didn't go there because I think he's disgusting. All of it was completely avoidable.
But whatever you decide, she is worth it. In my opinion the best LI in the entire game, especially if you wan't a more independent thinking Blake.