Dr. Lowe isn't just obsessed with bimbofication, he simply thinks that everyone should be happy, and in his mind Blake is better off being a careless, sex-crazed nympho. Which is probably what most people turn him into, so I don't see a contradiction here. You probably need to play through all seven variations of his big scene that I've made to get a grip on his personality, but to sum it up: the world is going to shit, there's no way for us all to survive unscathed, so let's just get naked and enjoy our final moments. Notice that he never brings up turning Melinda into bimbo. Cause she has power and authority. But for «small» people like Blake, Liam, Vanessa, Iris, etc it's a very valid path in his opinion.