It could be fun to have a picture where Nancy insists she's straight to a bunch of sexy women while looking at them with obvious lust and attraction, with a few sexy men passing right next to Nancy and her not even noticing.
Or maybe a series of panels where Nancy is working on a case and getting in increasingly sapphic situations and insisting she's straight, and then she solves the case and the guy she helped wants to ask her out as thanks she goes "sorry, I've already have plans" and the plans involves a sexy situation with a lady.
Like:
Panel 1:
Sexy mature businesswoman: "...and so, to summarize, I want you to find out who is hindering the children hospital's construction, stop them, and if you can rescue Tex Brashton, who has disappeared investigating the case two days ago. Are you up to the challenge?"
Nancy: "Absolutely! You can count on me, Ms. Bankscroft."
Sexy mature businesswoman: "Fantastic. I must say it's a relief to have such a confident detective on the case... especially one as attractive as you..."
Nancy: "I'm straight, but thank you."
Panel 2:
Harness-clad muscular Dominatrix: "*You* booked a session with me? Well I guess it shows you really can't judge as lusty, women-worshiping book by its naive-looking, innocent cover."
Nancy: "My apologies, but I'm straight. The only reason I've booked this session in your... dungeon is because it was the only way to talk with you quickly, and from what I've learned you're the last person to have spoken with Tex Brashton. I need your help to find him and where his investigation lead him. Can you help me, Ms. Heat?"
Harness-clad muscular Dominatrix: "Brashton's in trouble? Sure, I'll help... but from now on you call me Mistress Heat, got it?"
Panel 3:
Priestess lady, sitting on Nancy's face while another priestess is holding her legs: "Shhh, little one. Do not resist. In a few hours Tex Brashton will be dead, and thanks to his sacrifice our goddess will be here in person to make you her lesbian servant."
Nancy, muffled by the massive ass: "Ihmmmmm strht!"
Panel 4:
Tex Brashton, hunky Nathan Drake-style adventurer: "Please, Nancy, you've saved my life, the least I can do is invite you to diner."
Nancy: "Do not insist, Mr. Brashton. It would be inappropriate to accept such an invitation from a man who isn't my boyfriend."
Tex Brashton: "If that's the issue I'd gladly-"
Nancy: "Beside I already have plans."
Panel 5:
Nancy, in a fancy restaurant, holding a newspaper with Girl Detective Saves Children Hospital and Some Doofus headline: "I have to say, it feels great to be seen in your best light from time to time."
Sexy mature businesswoman, looking at Nancy with obvious desire: "And I won't allow anything that'd make you feel less than great tonight, Ms. Templeton. Say, where are you staying? I have a gift to be delivered to your room."
Nancy: "Oh my, I was so focused on solving the case I've completely forgotten about booking an hotel! And it's so late already..."
Sexy mature businesswoman: "Do not worry, you can stay at my mansion. I'll have a room ready and... prepared for you."
Nancy: "Wow, you're so kind, Ms. Bankscroft. I gladly accept."