I'm talking about second dead end where he took control of mc before wind guy took care of him.
The Eye just entertains Ella's words in that scene. There isn't really anything of value in this quote regarding evolutions.
Regarding perfect evolutions, natural evolutions, difference between natural and artificial, comparisons to the Big Trio, take everything with a grain of salt. There are a lot of hints that this is more complicated than it looks.
As for the quote regarding MC being already disqualified, that's Xanthe (after Tiffany/Michael evolution), trying to make a point that it's impossible to know if one will meet the requirements, which is why they prefer to use the serum for the final evolution. It was a "for all we know, you may have already failed them" hypothetical, not a true statement.