Yeah like Emily and the rest of the normal characters in game remaining human, become, irrelevant. As for a clean win, how about holding off the fuckers until Bernhardt arrives?
The twins could have served as a reason for a more humane mc to keep fighting, being some of his oldest friends. A link and anchor to staying human, something to protect. Now? They are just more freaks among an already bloated number of freaks. Protect them? Why they can take care of themselves. Just more characters to waste time watching in future battle sequences.
Alice and Michael it made sense for them to become monsters, it was a natural evolution of their charactes. Tiffany as well, Claudia it could be argued was iffy, but being Dexters kids, it can be excused.
But Amber and Liz? Why, what reason other than pointless drama? By becoming monsters same as almost every one else in the mcs life, they lose their value.
As characters the twins became a whole lot less interesting.
Now let me make a prediction, about the future of the story, since I did call out this bit days ago. When the mc finally awakens, he will not get the chance to enact bloody retribution, on Shen the two shitheads and the Doctor especially for touching the twins. At the last moment they will pull put some justification or some trump card that stops the mc from eating their brains.