There is no difference, maybe it'll mean something when the NTR route is implemented.I found a set from TGame that sort of work though I'd do things a bit differently - he skips over anything 'lewd' and blocks out most dialogue so there have been times when trying to work out what he did is difficult. Just ran into an issue when Darnell grabs Sara's butt in class and he neither shows the scene or indicates what he did....both options leave Darnell in the class room when I go back in but he does not have Darnell there which is weird. I checked MoonSpawn's videos and after working out which one I can see what he did....just not clear what the difference the two options cause in the game.
Currently there are no decisions that mean anything. (other than skipping the occasional scene)