Regarding the game-play, it is indeed a mouse killer... unless one enables some auto-repeater for clicks. Personally, I set single-clicks to my mouse wheel, which worked reasonably well (using xinput on Linux). The game-play still requires managing the timing so as not to over-click when the delay drugs run out. Eventually the cost of health points becomes so prohibitive such that drugs are effectively impossible to obtain
Based on that experience, the game-play could be changed that instead of mouse-clicking, something like this could work well too:
Holding down and releasing a key somewhat rhythmically, and arousal penalty only increases when missing the rhythm. The drugs would allow to disable the rhythm check for X seconds. This wouldn't change much in the game logic, but would save the mouse of people who don't know how to do how to configure the auto-repeater.