So, there's no way we can re-randomize the next floor by exiting the game and re-entering it? The idea is that by exiting the game, the next room will be randomized again. But how is that possible? Automatic saves occur when we move rooms, right? How do we know if the room has changed if we don't enter the next room?
So, the only way to re-randomize the rooms is to restart the round, right?
The save location is: User/your PC name/AppData/LocalLow/ScarletPaper/Thornsin
Make back up save just before you warp to the next level (example: from level 1-4 you want to go to level 1-5), if in the next level after you explore all the room there is none what you want like no breastfeeding chair, no merchant, no upgrade room for weapon, no triple chest, upgrade room is not what you desire (both are either give good karma or bad karma), no chest mimic, no painting trap, no infinite 1 coin or that infinite chest (when you re-enter, the coin is back again or the chest you opened before is filled again, but damn those thorn). So, the best option is replace your current save with back up and start over from that level (level 1-4).
Another trick, if after you defeat enemy in the room but there is no drop, just go back to title (don't restart the round) and continue, you will fight the enemy again and hopefully they drop coin or health orb, this is useful if you lack money but the merchant have a very good wares. This is the same in boss fight too, if after you defeat the boss and the special portal not appear just go back to title (don't restart the round) and after that repeat again the boss fight until the special portal appear. if the item is not the one you prioritized and you lack some soul, just go back to title again and repeat that boss fight