I just started playing the game, so I don't have a lot of feedback yet, but something I would strongly recommend is to rewrite the start of the game so that Natalie's arrival happens in the intro. Right now when the game plops you down on campus on day 1 the game's story hasn't really started and the player has no sense of aim or direction. This causes the pacing of the game to stumble, as a new player is likely to stop and and wonder "now what?". Natalie's arrival is what gives the story a sense of purpose and direction, so I believe it should happen before the player is set free to play on their own.
Edit: Another thing, the quest list is a bit badly designed. The horizontal bar under the headlines means that there is a separation between a quests headline and its content, but no separation between a quest's content and the headline of the next quest. Its more natural if the area between two horizontal bars all belongs to the same quest, rather than it being part of one quest and part of another.
Edit 2: The first time you arrive at the abandoned shop there is a separate link for "enter" and "enter the abandoned shop". The second should probably replace the first, rather than showing up in addition to it.
Edit 3: The date with Kasumi feels a bit weird, especially the fact that she doesn't react at all to the fact that you're cheating on her, nor does the main character expect her to react to this. I think the game would benefit from a clearer vision of what your relationship to Kasumi is, sometimes it feels very casual and other times very deep. I would suggest that a more casual relationship probably fits the story better, with how the main character only meets her friends at the start of the story. But that means that lines like the PC saying: " Kasumi! No matter what your thinking right now, I love you. Your irreplaceable, I don't care how you look. I will always love you. " during the date would need to be rewritten.
Edit 4: When the first mother's quest is active your mom is in the kitchen on Friday evenings (you have to meet her there to continue the quest) but she is also in her bedroom at the same time. She should be in the kitchen instead of in the bedroom, not in addition to it.
Edit 5: Fast traveling somewhere should probably close the fast travel interface, to save on clicking.
Edit 6: The first scene in the mom quest (drinking wine in the kitchen) takes you to your room afterwards, but there's nothing in the story to explain why you end up there. You should probably just stay in the kitchen.
Edit 7: Increasing corrupting influence doesn't always seem to actually increase it. I believe I've had it increase to 5 at least three times now.
Edit 8: The pacing of the game, and the way you progress, doesn't fit with the way that scenes are connected narratively. Kasumi says she got kicked out after her date with the main character, but in my game these events happened weeks apart.