Buncha stuff fits here, really. Here's a short list of some of the stuff that makes me outright ignore a game:
Really really bad art/Honey select at all (Tbh though, if the art is original, it's gotta be pretty bad for me to just never give a game a chance in the first place).
Gay tag.
Furry tag without incest.
Obviously Japanese game with generic hentai art without lots of tags of stuff I like.
Anything I know from previous experience is stupid/terrible.
Games with a female protagonist and the lesbian tag and no groping or exhibitionism or rape tag.
Any of those various well-animated games that look and sound like incest games but are adamantly against incest and don't have patches (Being a DIK, WVM, The DeLuca Family, et cetera. Fuck that shit. If you're making a slice of life/life sim/life whatever game, it should have incest in it as far as I'm concerned).
Anything with a title that sounds like it's trying to be an idiom in English and fails, and whose description is clearly written by somebody not fluent in English.
Herm/trans anything. If I'm honest, it's not a hard pass from me, except almost all those games are exclusively futa stuff and that's just not my scene. Same with lesbian stuff: it's not a turn-off unless that's all there is.
Note: you probably have different likes and dislikes from mine, so your list of what you ignore is probably different. That's totally fine! But this is the stuff that makes me not take a second look at a game.