What's more preferred and easier to work with RPGM or Ren'py

[fidless]

From my perspective, with determination, you can learn anything, but without that, everything else will flop flat. But that's irrelevant for this topic

 

[DawnCry]

People overall will vote ren'py because they don't want walking simulators to get scenes. The main question that you have to ask to yourself is "are you gonna need a battle system?", if not then use ren'py, if yes RPG maker.

But whatever you choose, take consideration of every detail like making custom menus, changing font and prepare the necessary mechanics if needed.