I've given up on quite a bunch of games/VNs for several reasons.
Before I start playing a game/VN, I always check out the tags and the screenshots. If the tags, the art style or the love interests don't interest me, I don't bother to download and play it. Saves me unneccessary frustration later on. (I've got rather strong optical preferences, so the used daz models and shapes/morphs matter a lot to me. F.e. I don't find small tits attractive at all. I can't help it, but too many flat-chested females in the cast and therefore unattractive potential love interests make me quit for good. But I also don't like the typical unnatural silicone implant look, while I'm totally into natural shaped breasts c-cup sized and above. It's a turn-on for me, if these are a little bit hanging or saggy. Therefore the milf tag is usually what I'm looking for. I also don't like it, if a dev uses daz models with unrealistically enlarged manga style eyes or some of those horrible daz teens, which don't have realistically looking faces and bodies. Those are a huge turn-off for me.) I also exclude abandoned games, because it's pointless to play one of those for me.
But still it happens, that I may lose interest in a game, which I liked in the beginning, because of appealing art, a convincing story and love interests, which are optically to my liking.
Sometimes a dev includes a fetish due to supporter demands later on [like futa/hermaphrodites, trans or ntr f.e.], which suddenly becomes dominant and which I don't like at all and then ruins the overall experience for me.
I've also given up on games I found too grindy and therefore tedious gameplay-wise like a lot of rpgm games and renpy sandbox games. There is a thin line between a reasonable amount of effort and build-up of tension for rewarding scenes. Most devs don't get that one right. I'm not playing erotic games for mindless tedious grind or permanent cockblocking/blue balling to keep things interesting, which just turns out to be frustrating eventually. (This doesn't mean, that I enjoy it, when sex scenes come with no effort or build-up at all, which would be the other extreme.)
Another reason for me to quit playing is when the writing becomes worse and therefore the overall plot turns totally illogically.
I also quit games for political reasons, f.e. if the dev wants to show off his personal political opinion within the game by dialogues and one-sided bad political jokes.
Least but not last I've quit games, which were just too generic, despite being popular, like those contemporary highschool games, featuring a mc, who is a virgin boy trying desperately to get laid or the typical incest game, where you play the lost son, which returns to his family for whatever reason and everyone is secretly into incest. These games bore me by now, because it has been done to death.