Quite the contrary, a girl that can take on tentacles, dogs, horses, orcs and whatever else comes for her is a keeper. I have a more open opinion regarding sex in games, if the woman is happy, Mr Tentacle is happy, nobody gets hurt, then it's all good. On the other hand, I dislike NTR and girls who are involved are no good for me, not because they had sex with another person/creature, but because they betrayed the trust the MC put in them.
For other stuff, a girl is never worse or better to me based on virginity, the existence of previous boyfriends, sexual taste, race, or sanity, but I keep away from girl representing fetishes I don't like such as lolis, dickgirls, preggos, family members and furries.