The ending is still very far away so I don't want to give absolute answers. But as of right now there is more than one ending planned.Will there be multiple endings which depend on what we decide to do in the game? I remember filming a porn video with a known artists but besides that, will there be a decision which will cause nothing but disaster, no turning point from that at all?
And in general I'm not a fan of "game overs". Especially since WVM is as long as it is/will be. There are negative consequence choices planned but they won't be cryptic and will be character specific. So if you make a bad choice a girl's romantic path could get blocked. (Though all romanceable girls are able to be romanced on a single playthrough. You won't have to choose between girls.)