Dude, you need a cookie? What are you trying to win here?
You are becoming less and less right trying to find a dumb hill to dumbly die on.
What it the heck does this:
Quests you should do first to enable all options:
Mira up until reading 2 Lucius “control your lust” (requires reading)
Bianca to learn lockpicking
John to learn forging"
Tell you about "strong anesthetic" in any way? It doesn't. At all. (BTW, standalone isn't being updated, you should be referring to the online version, which technically makes this information part of page 1.)
If you are stuck on Arianna, and made the major mistake of not processing what Lucien said in game months ago, reading step 21 "For the next step you must have completed Lucius quest and have visited his shop again a few days later to buy the strong anesthetic."
CAN CAUSE SOME CONFUSION IF YOU MADE THE ABSOLUTELY UNFORGIVABLE SIN OF MISSING ONE BIT OF DIALOGUE.
That confusion could be remedied if the walkthrough referred to the name Lucien sells it by, not by an easily missed bit of a synonym for it. At the time Lucien says it to you, Control your lust has been finished for over an in-game week, all of Lucien's quests have been finished at that point, so it's not even an issue of quest related dialogue.
So here is your cookie for being better than folks that have been confused by this. Thank god you are here to rub it in there faces that you are better than them.