I was concerned about this too and seeing as to how apparently there is a granny quest in the past and I'm at the point in the future where I have a daughter w/ auntie and cannot get back to the past to complete. No one has told me how or when to initiate that quest.I only played a very early version of this and thought about picking it up again, but all those questions about missable content are putting me off a bit. Can you actually miss content or even softlock yourself by doing things in the wrong order? Or is that just about stuff that still has to get implemented with future updates?