Not always. Alicia (the teacher, I think that's her name) doesn't appeal to me at all, in fact I went from doing her route until I knew that to get other LIs you had to continue it. Certainly the CTRL button has been very useful in this case.
Actually, in my case, one of the few fetishes (if you can call it that) I could say I like, creampies, loses much of its interest if the LI can't get pregnant (at least for me). And unless science advances a lot, I don't think a trans woman can get pregnant.