I use an adblocker, and Mixdrop frequently doesn't work on the first click, regardless what I'm trying to download from it. I'll have to click, hit back, click again, hit back, and then typically it works on the third or fourth try.
I use all things I listed in my comment, uBlock Origins, HTTPS Everywhere, Privacy Badger, and
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I also have do not track request added via browser, trackers blocked in VPN (along with ads and malware), and Edge has its own set of rules for popups and ads.
I click download, it starts it's download timer, 3, 2, 1, download button comes back, click it, takes all of 30 seconds.
Mixdrop looks like that for me, pretty bland site.
Also, Mixdrop is used as it's almost DMCA resistant, about 99.9%. Upload and forget. Things are still there like 4-5 years ago posted from here, while every other link is dead.