It's pretty amazing that I enjoyed doing DIK, Chick, and Neutral/Natural runs equally. At first it was grating to me to make only DIK choices, but it was funny as heck, and felt more in line with MC's history as an orphan abandoned by his first girl.
I knew lots of guys in college who went from sweet innocent kids to total dicks, especially after joining frats, so, it wasn't hard to imagine. Multiple saves and runs were great, romancing Sage, Quinn, Lily, etc., and beating down the sportos.
I generally enjoy "nice guy" runs in AVNs (it's fantasy, right? I'm an asshole normally, but would love to be a nicer person). The Chick run was my first one, and was absolutely fantastic. Josy, Josy/Maya, Jill, all were very emotionally satisfying runs to me.
When not worrying about alignment choices, and playing naturally, it was just as great, though more limiting without planning.