For those talking about the possibility of deaths and tragedy, although it's a possibility, the chances are very slim. As much as DPC puts drugs and prostitution and adultery and heart breaking situations into the game, most of the characters are still college kids. I treat this game as a college comedy/romance rather than a horror/thriller.
If DPC is any good in writing, this second game should be written as DPC strikes back in which he breaks out of his mold and smash everyone's expectations. Then in his third game, it will be the return of DPC, going back to the horror/thriller genre, and smashing everyone's prediction again.