Well, we had to get the hint with the candy from Lisa, so either she is a evil genius or just sensitive to Alcohol.
I don't think you have seen it in this game, since Max is still using alcohol candy. Why would he even bother if he knows she's faking? That would make the last third or half of the Alice quests complete nonsense.
Now that I think of it I am not sure I have seen it at all. I know there was some talk about in the forum, but I am not sure I actually saw it in any game.
If you find a savegame with that scene, I'd like to check it out. Or at least point out the part of the story when it's happening. Since there is no casual talk in this game, it must have been connected to a quest.
Ann was always as stupid as a empty can of yoghurt. In this game it's better than in others.