ZZZ honestly is nowhere even close to the popularity of Genshin or Honkai, so I wouldn't call it mainstream...yet. there are very little high quality 3D artists for ZZZ and Blob is comfortably sitting at the top at the moment, he took a leap of faith with that Nicole work and it worked so well, hell, the fact that he's doing Caesar at all, who in the community isn't even half as popular as Jane in terms of porn just shows he still has an eye for underrated girls, because she's extremely cute in game (and busty as hell)
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Outside of Pyra, there isn't really any worthy R34 candidate for Xenoblade and quite frankly, Pyra canonically having tits as big as her head helps her relevance a lot. The rest? Kinda shit out of luck with how boring their designs are, it's why he did Reisalin repeatedly too, cause she's already popular in the R34 sphere.
Also a side note, the ZZZ animations he made are clearly FAR higher quality than all of his other works in terms of animation fidelity and smoothness, so, while I think chasing a bigger audience was part of his plan, he clearly is quite passionate about the characters themselves too, and artists being passionate about the characters they animate ALWAYS results in amazing works... Just look at all these Tifa super simps who pour sweat and tears for their works (Nagoo, Hydra, JuicyNeko etc)