Ok, a quick troubleshooting:
1) Are you running it from inside the compressed file? (You'll be surprised how common this is)
If so...
2) Does the location of the game folder include special characters like !"#$%&/()=?
If so, remove any of those, special characters tend to mess some applications.
3) Is the folder of the game inside disc C:? As in, does it ask for Admin. Rights to launch?
Remove it from there, some games also won't start/launch properly when this is the case.
4) Try extracting the compressed file again, sometimes files get corrupted during extraction.
5) As far as I remember, the Doc has said that the RTP is no longer needed for this game, but just to double check, download the "RPG Maker VX Ace" file from
You must be registered to see the links
and install it, then launch the game again.