I mean, not when the dev want to include yennefer again.
Different MC/Goblin? Thats fine I guess.
The same Yen from last game? There need to be a canon chain of events to have it make sense in the sequel.
Or redcon everything but then what's the point of this game and have the next on titled as a sequel. A continuation.
If it's an all new cast? Then yes...the canon ending can be left open.
Food for thought.
If dev wants to have Yennefer in game and wants to change engine, it's looks more like remake.
Considering it's his first try and how short the game is, it's okey to start over making reboot with bigger scale.
I would prefer to have Yennefer as MC, simply to look on her instead of ugly goblin 90% of time, and removed cliche with addictive goblin sperm, having him using cunning and potions.
P.S. If making game without Yen:
Triss performing experiments that was forbidden by mage circle, goblin servant from circle discovers it and steals her notes.
He blackmails her, her pussy in exchange for silence. Triss has to ask circle to give him to her as helper. She lets him fuck her with disgust and keeps working on her project.
Her goal is to breed obedient species of monsters, and goblin meets Ciri who hesitantly agreed to help Triss, not knowing that she'll have to copulate with monsters.
Goblin will have a chance to corrupt both women, Triss by proving he's perfect partner for her crazy experiments, and Ciri by pushing her into pregnancy obsession and love for monster cocks.